Tramutola, A., Lanzillotta, C., Di Domenico, F., Head, E., Butterfield, D., Perluigi, M., & Barone, E. (2020). Brain insulin resistance triggers early onset Alzheimer disease in Down syndrome. Neurobiology of Disease, 137, 104772. https://doi.org/10.1016/j.nbd.2020.104772

Tramutola, A., Pupo, G., Di Domenico, F., Barone, E., Arena, A., Lanzillotta, C., … Perluigi, M. Activation of p53 in Down Syndrome and in the Ts65Dn Mouse Brain is Associated with a Pro-Apoptotic Phenotype. Journal of Alzheimer’s Disease : JAD, 52(1), 359-371. https://doi.org/10.3233/JAD-151105 (Original work published 2016)

Tramutola, A., Di Domenico, F., Barone, E., Perluigi, M., & Butterfield, D. It Is All about (U)biquitin: Role of Altered Ubiquitin-Proteasome System and UCHL1 in Alzheimer Disease. Oxidative Medicine and Cellular Longevity, 2016, 2756068. https://doi.org/10.1155/2016/2756068 (Original work published 2016)

Barone, E., Di Domenico, F., Cassano, T., Arena, A., Tramutola, A., Lavecchia, M., … Perluigi, M. (2016). Impairment of biliverdin reductase-A promotes brain insulin resistance in Alzheimer disease: A new paradigm. Free Radical Biology & Medicine, 91, 127-42. https://doi.org/10.1016/j.freeradbiomed.2015.12.012

Di Domenico, F., Tramutola, A., & Butterfield, D. (2017). Role of 4-hydroxy-2-nonenal (HNE) in the pathogenesis of alzheimer disease and other selected age-related neurodegenerative disorders. Free Radical Biology & Medicine, 111, 253-261. https://doi.org/10.1016/j.freeradbiomed.2016.10.490

Tramutola, A., Arena, A., Cini, C., Butterfield, D., & Barone, E. (2017). Modulation of GLP-1 signaling as a novel therapeutic approach in the treatment of Alzheimer’s disease pathology. Expert Review of Neurotherapeutics, 17(1), 59-75. https://doi.org/10.1080/14737175.2017.1246183

Tramutola, A., Di Domenico, F., Barone, E., Arena, A., Giorgi, A., di Francesco, L., … Perluigi, M. (2017). Polyubiquitinylation Profile in Down Syndrome Brain Before and After the Development of Alzheimer Neuropathology. Antioxidants & Redox Signaling, 26(7), 280-298. https://doi.org/10.1089/ars.2016.6686 (Original work published 2017)

Perluigi, M., Picca, A., Montanari, E., Calvani, R., Marini, F., Matassa, R., … Barone, E. (2022). Aberrant crosstalk between insulin signaling and mTOR in young Down syndrome individuals revealed by neuronal-derived extracellular vesicles. Alzheimer’s & Dementia : The Journal of the Alzheimer’s Association, 18(8), 1498-1510. https://doi.org/10.1002/alz.12499

Lanzillotta, C., Tramutola, A., Di Giacomo, G., Marini, F., Butterfield, D., Di Domenico, F., … Barone, E. (2021). Insulin resistance, oxidative stress and mitochondrial defects in Ts65dn mice brain: A harmful synergistic path in down syndrome. Free Radical Biology & Medicine, 165, 152-170. https://doi.org/10.1016/j.freeradbiomed.2021.01.042

Perluigi, M., Tramutola, A., Pagnotta, S., Barone, E., & Butterfield, D. (2020). The BACH1/Nrf2 Axis in Brain in Down Syndrome and Transition to Alzheimer Disease-Like Neuropathology and Dementia. Antioxidants (Basel, Switzerland), 9(9). https://doi.org/10.3390/antiox9090779 (Original work published 2020)