Evaluation of drug mechanism and efficacy of a novel anti-angiogenic agent, TTAC-0001, using multi-modality bioimaging in a mouse breast cancer orthotopic model.
| Author | |
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| Abstract | :
Targeting of vascular endothelial growth factor receptors (VEGFRs) has potential anti-angiogenic effects because VEGFR-2 is the major signaling regulator of VEGF/VEGFR pathways. We aimed to elucidate the drug mechanism and anti-tumor efficacy of TTAC-0001, a novel, fully human anti-VEGFR-2/KDR monoclonal antibody, in mouse orthotopic breast cancer model using multi-modal bioimaging. |
| Year of Publication | :
0
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| Journal | :
PloS one
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| Volume | :
13
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| Issue | :
1
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| Number of Pages | :
e0187063
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| Date Published | :
2018
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| URL | :
http://dx.plos.org/10.1371/journal.pone.0187063
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| DOI | :
10.1371/journal.pone.0187063
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| Short Title | :
PLoS One
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| Download citation |