Plasma TNF-α and Soluble TNF Receptor Levels after Doxorubicin with or without Co-Administration of Mesna-A Randomized, Cross-Over Clinical Study.
| Author | |
|---|---|
| Abstract | :
Chemotherapy-induced cognitive impairment (CICI) is a common sequelae of cancer therapy. Recent preclinical observations have suggested that CICI can be mediated by chemotherapy-induced plasma protein oxidation, which triggers TNF-α mediated CNS damage. This study evaluated sodium-2-mercaptoethane sulfonate (Mesna) co-administration with doxorubicin to reduce doxorubicin-induced plasma protein oxidation and resultant cascade of TNF-α, soluble TNF receptor levels and related cytokines. |
| Year of Publication | :
0
|
| Journal | :
PloS one
|
| Volume | :
10
|
| Issue | :
4
|
| Number of Pages | :
e0124988
|
| Date Published | :
2015
|
| URL | :
https://dx.plos.org/10.1371/journal.pone.0124988
|
| DOI | :
10.1371/journal.pone.0124988
|
| Short Title | :
PLoS One
|
| Download citation |